THE CHALLENGE WITH FLUID OVERLOAD

• Fluid overload is associated with significant increases in mortality in pediatric patients^1,2
• In a pediatric study, a 3% increase in mortality was observed for every 1% increase in fluid overload (FO),^1,2 children with more than 20% FO had an odds ratio for mortality of 8.5 compared with children with less than 20% FO^1,2
• Diuretics and adult CRRT devices can be poorly tolerated by pediatric patients^3-6
• Ultrafiltration therapy with a device containing small extracorporeal volume (ECV) may be better tolerated than CRRT machines with larger ECV in relation to patient blood volume⁷

PREDICTABLE OUTCOMES WITH AQUADEX

SAFE

• Safe and effective for pediatric patients (≥ 20kg) who are fluid overloaded and fail diuretics
• Only requires approximately 35 mL of ECV in the blood circuit
• Low maximum blood flow rate (40mL/min) helps prevent hemodynamic stress associated with excessive fluid removal
• Low maximum ultrafiltration rate (500 mL/hr) reduces the risk associated with removing fluid at high rates in smaller patients

GENTLE

• An alternative to diuretics and other CRRT therapies that can be less effective, less efficient, or not well-tolerated^3-6

SMART

• Filter Alert prompts action to extend filter life and reduce therapy time
• Hct informs therapy titration and termination decisions
• Sv02 helps determine the amount of oxygen delivered to the body and guide therapy decisions
• Track fluid removed more easily compared with today’s manual process