Simplified, Predictable Fluid Management

A Trusted Ultrafiltration System Designed for Patients When Diuretics Fail

The Aquadex SmartFlow® system delivers controlled, predictable isotonic fluid removal for patients with fluid overload, helping reduce readmissions and improve outcomes. For hospitals, Aquadex offers a streamlined solution that is cost-effective, workflow-friendly, and backed by comprehensive clinical support.

How It Works Schedule a Demo

How Aquadex Ultrafiltration Reduces Rehospitalizations: A Decade of Evidence

Aquadex ultrafiltration therapy offers a proven, real-world solution for managing acute fluid overload, demonstrating significant improvements in clinical outcomes for patients across the care continuum.

10 yr

Comprehensive study on long-term effectiveness

14 .58

Liters of fluid removed on average¹

43 ×

More likely to succeed than adjustable loop diuretics²

READ THE CLINICAL EVIDENCE

How Aquadex Works

Safe, Predictable Fluid Removal with Minimal Staff Burden

Aquadex provides a simplified ultrafiltration process that removes excess fluid directly from the blood while maintaining essential electrolytes.

Insert Central or Peripheral IV Access

Blood is Gently Circulated Through the Aquadex Filter

Excess Fluid is Removed With Precision

Balanced Blood Returns to the Patient

3 Components of the Aquadex SmartFlow System

The console allows caregivers precise control of ultrafiltration therapy. The peripheral catheter draws blood from and returns blood to the patient. Finally, the blood circuit set filters the patient’s blood and removes excess water and salt.

1

Download Aquadex Console Product Brochure

2

Download Aquadex Peripheral Catheter Product Brochure

3

Download Aquadex Blood Circuit Set Product Brochure

Who Aquadex Helps

  • Predictable Control with Less Complexity.⁴
  • Aquadex is FDA-cleared for ultrafiltration therapy in pediatric patients weighing 20 kg or more.
  • 60% Reduction in Heart Failure Events.³
Critical Care Pediatrics Cardiology
  • Predictable Control with Less Complexity.⁴

    In critically ill patients, fluid retention can complicate recovery and increase mortality risk. Aquadex delivers predictable control with less complexity than CRRT, empowering clinicians to stabilize patients and optimize outcomes.

    Read the clinical studies:

  • Aquadex is FDA-cleared for ultrafiltration therapy in pediatric patients weighing 20 kg or more.

    Children with acute kidney injury or post-surgical fluid overload require careful, precise management. Aquadex is successfully used in pediatric nephrology, including PICU patients, offering safety and control when it matters most.

    It is safe and effective for appropriately selected pediatric patients weighing 20 kg or more, with a blood circuit extracorporeal volume of approximately 35 mL, minimizing hemodynamic stress.

  • 60% Reduction in Heart Failure Events.³

    Patients with heart failure and fluid overload often face diuretic resistance and frequent readmissions. Aquadex provides a proven diuretic alternative, reducing strain on the kidneys and improving long-term outcomes.

    A 2025 study published in JACC: Heart Failure found that patients treated with Aquadex therapy experienced a 60% reduction in heart failure events at 30 days compared to those receiving standard care.

    Read the clinical studies:

Trusted by Clinicians, Proven for Inpatients and Outpatients

Aquadex is supported by a growing body of peer-reviewed studies across cardiology, nephrology, pediatric, and outpatient populations. Clinical evidence consistently demonstrates its safety, effectiveness, and ability to reduce hospital readmissions.

53 %

Fewer Readmissions5

22 K

Patients Worldwide Treated with Aquadex Therapy6

$4 K

Average Savings Per Patient7

See Clinical Studies

Benefits for hospitals

Implementation Made Simple

Designed for workflow efficiency, Aquadex requires only IV access and trained nursing staff. Compared to dialysis or CRRT, it is simpler, faster, and less resource-intensive.

Reduced Staff Burden

Nursing-led therapy that allows for a 4-to-1 patient-nurse ratio.

Easy Adoption

Straightforward onboarding and in-service training.

Measurable ROI

Fewer readmissions, reduced ICU days, and optimized diuretic usage.8

Where to Find Aquadex

Our Growing Network of Care

Aquadex Ultrafiltration Therapy is available in hospitals in cities throughout the country. See all providers on this map.

  • Available
  • Not Available
UTMB Health
301 University Blvd, Galveston, TX 77555
(490) 772-2222
UK HealthCare
1000 S Limestone, Lexington, KY 40536
(859) 257-1000

Programmatic Fluid Management

Take the Next Step

Bring the benefits of Aquadex to your patients and your hospital.

Whether you’re a clinician seeking a safe, evidence-based solution for fluid management or an administrator focused on ROI, Aquadex offers a proven path forward.

Contact Us
1

10 years of real world data with UF for ADHF patients

2

Ultrafiltration for Management of Decompensated Heart Failure: A Reappraisal of AVOID-HF

3

Ultrafiltration for Management of Decompensated Heart Failure: A Reappraisal of AVOID-HF

4

Extracorporeal Ultrafiltration for Fluid Overload in Heart Failure: Current Status and Prospects for Further Research

5

Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure

6

Utilization figures are based up Company estimates, including certain good faith assumptions of the number of blood circuits used per adult and per pediatric procedures, such that patients served equals total number of units sold divided by a per-procedure estimate of circuit used per adult and pediatric patients.

7

Outcomes of Ultrafiltration in community-based hospitals

8

Outcomes of Ultrafiltration in community-based hospitals